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Article

A small-molecule approach to restore female sterility phenotype targeted by a homing suppression gene drive in the fruit pest Drosophila suzukii.

PLoS genetics - 1 Apr 2024

Ma Suhan, Ni Xuyang, Chen Shimin, Qiao Xiaomu, Xu Xuejiao, Chen Weizhe, Champer Jackson, Huang Jia

Abstract excerpt

CRISPR-based gene drives offer promising prospects for controlling disease-transmitting vectors and agricultural pests. A significant challenge for successful suppression-type drive is the rapid evolution of resistance alleles. One approach to mitigate the development of resistance involves targeting functionally constrained regions using multiple gRNAs. In this study, we constructed a 3-gRNA homing gene drive...

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Identifiers

PMID: 38578788
DOI: 10.1371/journal.pgen.1011226
PMCID: PMC11023630

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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