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Article

RBM10 C761Y mutation induced oncogenic ASPM isoforms and regulated β-catenin signaling in cholangiocarcinoma.

Journal of experimental & clinical cancer research : CR - 4 Apr 2024

Chang Jiang, Zhang Yaodong, Zhou Tao, Qiao Qian, Shan Jijun, Chen Yananlan, Jiang Wangjie, Wang Yirui, Liu Shuochen, Wang Yuming, Yu Yue, Li Changxian, Li Xiangcheng

Abstract excerpt

BACKGROUND: Cholangiocarcinoma (CCA) comprises a heterogeneous group of biliary tract cancer. Our previous CCA mutation pattern study focused on genes in the post-transcription modification process, among which the alternative splicing factor RBM10 captured our attention. However, the roles of RBM10 wild type and mutations in CCA remain unclear. METHODS: RBM10 mutation spectrum in CCA was clarified using our...

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Identifiers

PMID: 38576051
DOI: 10.1186/s13046-024-03030-x
PMCID: PMC10993532

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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