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Article

ARID1A alterations and their clinical significance in cholangiocarcinoma

3 Dec 2020

Abstract excerpt

Background ARID1A is a member of the SWI/SNF chromatin remodeling complex. It functions as a tumor suppressor and several therapeutic targets in ARID1A-mutated cancers are currently under development, including EZH2. A synthetic lethal relationship between ARID1A and EZH2 has been revealed in several tumor entities. Although genomic alterations of ARID1A have been described in various cancers, no study has...

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PMID: 33344089
DOI: 10.7717/peerj.10464

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