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Article

The effect of polygenic liability to mental disorders on COVID-19 outcomes in people with depression: the mediating role of anxiety.

Psychological medicine - 1 Nov 2024

Monistrol-Mula Anna, Felez-Nobrega Mireia, Byrne Enda M, Lind Penelope A, Hickie Ian B, Martin Nicholas G, Medland Sarah E, Colodro-Conde Lucía, Mitchell Brittany L

Abstract excerpt

BACKGROUND: Genetic vulnerability to mental disorders has been associated with coronavirus disease-19 (COVID-19) outcomes. We explored whether polygenic risk scores (PRSs) for several mental disorders predicted poorer clinical and psychological COVID-19 outcomes in people with pre-existing depression. METHODS: Data from three assessments of the Australian Genetics of Depression Study (N = 4405; 52.2 years ± 14.9;...

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Identifiers

PMID: 39552393
DOI: 10.1017/S0033291724001983
PMCID: PMC11650167

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