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Article

Polygenic risk, stressful life events and depressive symptoms in older adults: a polygenic score analysis.

Psychological medicine - 1 Jun 2015

Musliner K L, Seifuddin F, Judy J A, Pirooznia M, Goes F S, Zandi P P

Abstract excerpt

BACKGROUND: Previous studies suggest that the relationship between genetic risk and depression may be moderated by stressful life events (SLEs). The goal of this study was to assess whether SLEs moderate the association between polygenic risk of major depressive disorder (MDD) and depressive symptoms in older adults. METHOD: We used logistic and negative binomial regressions to assess the associations between...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25488392
DOI: 10.1017/S0033291714002839
PMCID: PMC4412793

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