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Article

Reassessing human MHC-I genetic diversity in T cell studies.

Scientific reports - 4 Apr 2024

Slieker Roderick C, Warmerdam Daniël O, Vermeer Maarten H, van Doorn Remco, Heemskerk Mirjam H M, Scheeren Ferenc A

Abstract excerpt

The Major Histocompatibility Complex class I (MHC-I) system plays a vital role in immune responses by presenting antigens to T cells. Allele specific technologies, including recombinant MHC-I technologies, have been extensively used in T cell analyses for COVID-19 patients and are currently used in the development of immunotherapies for cancer. However, the immense diversity of MHC-I alleles presents challenges....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38575727
DOI: 10.1038/s41598-024-58777-2
PMCID: PMC10995142

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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