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Article

No genetic causal association between circulating alpha-tocopherol levels and osteoarthritis, a two-sample Mendelian randomization analysis.

Scientific reports - 2 May 2024

Cui Aiyong, Xiao Peilun, Wang Pengfei, Wang Hu, Cong Yuxuan, Fan Zhiqiang, Wei Xing, Zhuang Yan

Abstract excerpt

The causal association between vitamin E status and osteoarthritis (OA) remains controversial in previous epidemiological studies. We employed a Mendelian randomization (MR) analysis to explore the causal relationship between circulating alpha-tocopherol levels (main forms of vitamin E in our body) and OA. The instrumental variables (IVs) of circulating alpha-tocopherol levels were obtained from a Genome-wide...

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alpha-Tocopherol
Genetic Predisposition to Disease
Genome-Wide Association Study
Mendelian Randomization Analysis
Osteoarthritis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Single Nucleotide

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PMID: 38698019
DOI: 10.1038/s41598-024-60676-5
PMCID: PMC11066079

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