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Article

Methylation levels of the IL10 gene in peripheral blood are related to the intractability of Graves' disease.

Clinical immunology (Orlando, Fla.) - 1 Jun 2024

Kinoshita Riku, Inoue Naoya, Iwatani Yoshinori, Noguchi Yusuke, Hidaka Yoh, Watanabe Mikio

Abstract excerpt

The prognosis of autoimmune thyroid diseases (AITDs), including Hashimoto's disease (HD) and Graves' disease (GD), is difficult to predict. DNA methylation regulates gene expression of immune mediating factors. Interleukin (IL)-10 is a Th2 cytokine that downregulates inflammatory cytokines produced by Th1 cells. To clarify the role of methylation of the IL10 gene in the prognosis of AITD, we evaluated the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 38570004
DOI: 10.1016/j.clim.2024.110196

Genes

IL10

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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