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Article

Functional polymorphisms affecting Th1 differentiation are associated with the severity of autoimmune thyroid diseases.

Endocrine journal - 28 Jul 2017

Inoue Naoya, Watanabe Mikio, Nakaguchi Azusa, Ueda Daishi, Kawaguti Hayaka, Hidaka Yoh, Iwatani Yoshinori

Abstract excerpt

The prognosis for autoimmune thyroid diseases (AITDs), such as Hashimoto's disease (HD) and Graves' disease (GD), varies among patients. Interleukin (IL)-12 and IL-18 also induce Th1 differentiation, and SOCS1 (Suppressor of cytokine signaling 1) and TIM-3 (T cell immunoglobulin and mucin domain-3) are known to be negative regulators of Th1 cells. To clarify the association of functional polymorphisms in the...

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Identifiers

PMID: 28515387
DOI: 10.1507/endocrj.EJ16-0551

Genes

SOCS1

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