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Article

Effect of DNA methylation at the CTLA4 gene on the clinical status of autoimmune thyroid diseases.

Clinical immunology (Orlando, Fla.) - 1 Oct 2024

Ohtani Hiroki, Inoue Naoya, Iwatani Yoshinori, Takeno Yuri, Arakawa Yuya, Hidaka Yoh, Watanabe Mikio

Abstract excerpt

The pathogenesis and manifestation of autoimmune thyroid diseases (AITDs), Graves' disease (GD), and Hashimoto's disease (HD) are associated with T cell activation. Cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) plays a crucial role in the regulation of T cell activation. DNA methylation levels of eight CpG sites in the CTLA4 gene and expression levels of soluble CTLA-4 were examined. Methylation levels of...

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Identifiers

PMID: 39142493
DOI: 10.1016/j.clim.2024.110338

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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