Article
Population-based BRCA germline mutation screening in the Han Chinese identifies individuals at risk of BRCA mutation-related cancer: experience from a clinical diagnostic center from greater Shanghai area.
BMC cancer - 2 Apr 2024
Wu Zhiyuan, Zhang Qingyun, Jin Yiting, Zhang Xinju, Chen Yanli, Yang Can, Tang Xuemei, Jiang Haowen, Wang Xiaoyi, Zhou Xinli, Yu Feng, Wang Bing, Guan Ming
Abstract excerpt
BACKGROUND: Deleterious BRCA1/2 (BRCA) mutation raises the risk for BRCA mutation-related malignancies, including breast, ovarian, prostate, and pancreatic cancer. Germline variation of BRCA exhibits substantial ethnical diversity. However, there is limited research on the Chinese Han population, constraining the development of strategies for BRCA mutation screening in this large ethnic group. METHODS: We profile...
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