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Article

Genomic Landscape of 6597 Hong Kong HBOC Patients: Implications for Beyond-BRCA Multi-Gene Panel Testing and Cancer Surveillance.

International journal of molecular sciences - 24 Aug 2026

Kwong Ava, Ho Cecilia Y S, Tey Sze Keong, Au Chun Hang, Ma Edmond S K

Abstract excerpt

Breast cancer remains highly prevalent, where the lifetime risk before age 75 is one in 13. However, known genetic factors were only identified in 14.7% of cases in our Hong Kong Hereditary Breast Cancer Family Registry. Our current local policy for genetic testing does not cover the detection of beyond BRCA1/2. Here we highlight the clinical value of extending testing to beyond BRCA susceptibility genes for...

Read the complete abstract on PubMed

Topics

Humans
Female
Hong Kong
Germ-Line Mutation
Genetic Predisposition to Disease
Genetic Testing

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Hereditary Breast and Ovarian Cancer Syndrome

Middle Aged

Adult

Aged

High-Throughput Nucleotide Sequencing

BRCA1 Protein

BRCA2 Protein

Breast Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 42737475
DOI: 10.3390/ijms27177572
PMCID: PMC13566287

Genes

BARD1
BRCA1
PALB2
TP53
ATM
PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 25 Oct 2026.

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