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Germline variants profiling of BRCA1 and BRCA2 in Chinese Hakka breast and ovarian cancer patients.

BMC cancer - 2 Aug 2022

Zhang Yunuo, Wu Heming, Yu Zhikang, Li Liang, Zhang Jinhong, Liang Xinhong, Huang Qingyan

Abstract excerpt

OBJECTIVE: To investigate the prevalence and spectrum of BRCA1 and BRCA2 mutations in Chinese Hakka patients with breast and ovarian cancer. METHODS: A total of 1,664 breast or ovarian cancer patients were enrolled for genetic testing at our hospital. Germline mutations of the BRCA gene were analysed by next-generation sequencing, including the coding regions and exon intron boundary regions. RESULTS: The 1,664...

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Identifiers

PMID: 35918668
DOI: 10.1186/s12885-022-09943-0
PMCID: PMC9347172

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