Article
The presence of a chromosomal abnormality in cytopenia without dysplasia identifies a category of high-risk clonal cytopenia of unknown significance.
Genes, chromosomes & cancer - 1 Mar 2023
Brett Victor-Emmanuel, Lechevalier Nicolas, Trimoreau Franck, Dussiau Charles, Dimicoli-Salazar Sophie, Coster Lucie, Luquet Isabelle, Nadal Nathalie, Ribourtout Bénédicte, Chapiro Elise, Lefebvre Christine, Tondeur Sylvie, Balducci Estelle, Nguyen-Khac Florence, Borie Claire, Radford-Weiss Isabelle, Barin Carole, Eclache Virginie, Mansier Olivier, Bidet Audrey
Abstract excerpt
Myelodysplastic syndromes (MDS) are hematological malignancies classically defined by the presence of cytopenia(s) and dysmorphic myeloid cells. It is now known that MDS can be preceded by a pre-malignant condition called clonal cytopenia of unknown significance (CCUS), which associates a clonality marker with cytopenia in the absence of criteria of dysplasia. However, to date, it is not clear whether chromosomal...
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