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Novel Inhibitors to MmpL3 Transporter of <i>Mycobacterium tuberculosis</i> by Structure-Based High-Throughput Virtual Screening and Molecular Dynamics Simulations

12 Mar 2024

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High Resolution Image Download MS PowerPoint Slide Tuberculosis (TB)-causing bacterium Mycobacterium tuberculosis (Mtb) utilizes mycolic acids for building the mycobacterial cell wall, which is critical in providing defense against external factors and resisting antibiotic action. MmpL3 is a secondary resistance nodulation division transporter that facilitates the coupled transport of mycolic acid precursor into...

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PMID: 38559933
DOI: 10.1021/acsomega.3c08401

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