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Molecular docking, validation, dynamic simulation and pharmacokinetic prediction of natural compounds against <i>Mycobacterium tuberculosis</i> Beta-lactamase BlaC

2025-01-08

Abstract excerpt

<h4>ABSTRACT</h4> Tuberculosis, caused by Mycobacterium tuberculosis ranks second globally in terms of infectious disease-related deaths, after HIV. The resistance of M. tuberculosis to existing beta-lactam antibiotics is primarily due to chromosomally encoded gene blaC, which can hydrolyse predominantly available beta-lactam antibiotics. Despite the available beta-lactamase inhibitors with beta-lactam ring suc...

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Literature Corpus work
3178ad45-6a9b-589e-8d7b-076bbb3b0d3a
DOI
10.1101/2025.01.07.631633
Open publication

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