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Article

Cryo-EM structure and resistance landscape of M. tuberculosis MmpL3: An emergent therapeutic target.

Structure (London, England : 1993) - 7 Oct 2021

Adams Oliver, Deme Justin C, Parker Joanne L, Fowler Philip W, Lea Susan M, Newstead Simon

Abstract excerpt

Tuberculosis (TB) is the leading cause of death from a single infectious agent and in 2019 an estimated 10 million people worldwide contracted the disease. Although treatments for TB exist, continual emergence of drug-resistant variants necessitates urgent development of novel antituberculars. An important new target is the lipid transporter MmpL3, which is required for construction of the unique cell envelope...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34242558
DOI: 10.1016/j.str.2021.06.013
PMCID: PMC8752444

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