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Article

A conserved NR5A1-responsive enhancer regulates SRY in testis-determination

30 Mar 2024

Abstract excerpt

The Y-linked SRY gene initiates mammalian testis-determination. However, how the expression of SRY is regulated remains elusive. Here, we demonstrate that a conserved steroidogenic factor-1 (SF-1)/NR5A1 binding enhancer is required for appropriate SRY expression to initiate testis-determination in humans. Comparative sequence analysis of SRY 5' regions in mammals identified an evolutionary conserved...

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PMID: 38555298
DOI: 10.1038/s41467-024-47162-2

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