Article
Two redundant transcription factor binding sites in a single enhancer are essential for mammalian sex determination.
Nucleic acids research - 10 Jun 2024
Ridnik Meshi, Abberbock Elisheva, Alipov Veronica, Lhermann Shelly Ziv, Kaufman Shoham, Lubman Maor, Poulat Francis, Gonen Nitzan
Abstract excerpt
Male development in mammals depends on the activity of the two SOX gene: Sry and Sox9, in the embryonic testis. As deletion of Enhancer 13 (Enh13) of the Sox9 gene results in XY male-to-female sex reversal, we explored the critical elements necessary for its function and hence, for testis and male development. Here, we demonstrate that while microdeletions of individual transcription factor binding sites (TFBS)...
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