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Global Genome Analysis of the Downstream Binding Targets of Testis Determining Factor SRY and SOX9

12 Sept 2012

Abstract excerpt

A major event in mammalian male sex determination is the induction of the testis determining factor Sry and its downstream gene Sox9. The current study provides one of the first genome wide analyses of the downstream gene binding targets for SRY and SOX9 to help elucidate the molecular control of Sertoli cell differentiation and testis development. A modified ChIP-Chip analysis using a comparative hybridization...

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Share to Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
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PMID: 22984422
DOI: 10.1371/journal.pone.0043380

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Related research

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Research trail→

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Global Genome Analysis of the Downstream Binding Targets of Testis Determining Factor SRY and SOX9PMID 22984422Read ↗

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Human sex reversal is caused by duplication or deletion of core enhancers upstream of SOX9Semantic proximity Read ↗

SRY Induced TCF21 Genome-Wide Targets and Cascade of bHLH Factors During Sertoli Cell Differentiation and Male Sex Determination in Rats1Semantic proximity Read ↗

Basic Helix-Loop-Helix Transcription Factor TCF21 Is a Downstream Target of the Male Sex Determining Gene SRYSemantic proximity Read ↗

Sry and Sox9: mammalian testis-determining genesSemantic proximity Read ↗

Diverse Regulation but Conserved Function: SOX9 in Vertebrate Sex DeterminationSemantic proximity Read ↗

Two redundant transcription factor binding sites in a single enhancer are essential for mammalian sex determination.Semantic proximity Read ↗

A conserved NR5A1-responsive enhancer regulates SRY in testis-determinationSemantic proximity Read ↗

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SOX Genes and Their Role in Disorders of Sex DevelopmentSemantic proximity Read ↗

Turning on the male--SRY, SOX9 and sex determination in mammals.Semantic proximity Read ↗

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