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Article

Steroidogenic factor-1 (SF-1, NR5A1) and human disease.

Molecular and cellular endocrinology - 10 Apr 2011

Ferraz-de-Souza Bruno, Lin Lin, Achermann John C

Abstract excerpt

Steroidogenic factor-1 (SF-1, Ad4BP, encoded by NR5A1) is a key regulator of adrenal and reproductive development and function. Based upon the features found in Nr5a1 null mice, initial attempts to identify SF-1 changes in humans focused on those rare individuals with primary adrenal failure, a 46,XY karyotype, complete gonadal dysgenesis and Müllerian structures. Although alterations affecting DNA-binding of...

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Identifiers

PMID: 21078366
DOI: 10.1016/j.mce.2010.11.006
PMCID: PMC3057017

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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