Article
SRY protein function in sex determination: thinking outside the box.
Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology - 1 Jan 2012
Zhao Liang, Koopman Peter
Abstract excerpt
Even though the mammalian sex-determining gene Sry has been intensively studied for the two decades since its discovery, the regions outside the conserved HMG box DNA-binding domain have received less attention due to a lack of sequence conservation and of obvious structural/functional motifs. Here, we summarize the available evidence for function beyond the HMG box, identify the known and postulated biochemical...
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