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Article

pADP-ribosylation regulates the cytoplasmic localization, cleavage, and pro-apoptotic function of HuR.

Life science alliance - 1 Jun 2024

Ashour Kholoud, Sali Sujitha, Aldoukhi Ali H, Hall Derek, Mubaid Souad, Busque Sandrine, Lian Xian Jin, Gagné Jean-Philippe, Khattak Shahryar, Di Marco Sergio, Poirier Guy G, Gallouzi Imed-Eddine

Abstract excerpt

HuR (ElavL1) is one of the main post-transcriptional regulators that determines cell fate. Although the role of HuR in apoptosis is well established, the post-translational modifications that govern this function remain elusive. In this study, we show that PARP1/2-mediated poly(ADP)-ribosylation (PARylation) is instrumental in the pro-apoptotic function of HuR. During apoptosis, a substantial reduction in HuR...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 38538092
DOI: 10.26508/lsa.202302316
PMCID: PMC10972696

Genes

PARP1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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