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Article

Poly (ADP) Ribose Glycohydrolase Can Be Effectively Targeted in Pancreatic Cancer

4 Jul 2019

Abstract excerpt

Abstract Patients with metastatic pancreatic ductal adenocarcinoma (PDAC) have an average survival of less than 1 year, underscoring the importance of evaluating novel targets with matched targeted agents. We recently identified that poly (ADP) ribose glycohydrolase (PARG) is a strong candidate target due to its dependence on the pro-oncogenic mRNA stability factor HuR (ELAVL1). Here, we evaluated PARG as a...

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PMID: 31273064
DOI: 10.1158/0008-5472.can-18-3645

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Poly (ADP) Ribose Glycohydrolase Can Be Effectively Targeted in Pancreatic CancerPMID 31273064Read ↗

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