Article
PARP1 promotes gene expression at the post-transcriptiona level by modulating the RNA-binding protein HuR.
Nature communications - 8 Mar 2017
Ke Yueshuang, Han Yanlong, Guo Xiaolan, Wen Jitao, Wang Ke, Jiang Xue, Tian Xue, Ba Xueqing, Boldogh Istvan, Zeng Xianlu
Abstract excerpt
Poly(ADP-ribosyl)ation (PARylation) is mainly catalysed by poly-ADP-ribose polymerase 1 (PARP1), whose role in gene transcription modulation has been well established. Here we show that, in response to LPS exposure, PARP1 interacts with the adenylateuridylate-rich element-binding protein embryonic lethal abnormal vision-like 1 (Elavl1)/human antigen R (HuR), resulting in its PARylation, primarily at site D226....
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