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Unique Spatial Transcriptomic Profiling of the Murine Femoral Fracture Callus: A Preliminary Report

16 Mar 2024

Abstract excerpt

Fracture callus formation is a dynamic stage of bone activity and repair with precise, spatially localized gene expression. Metastatic breast cancer impairs fracture healing by disrupting bone homeostasis and imparting an altered genomic profile. Previous sequencing techniques such as single-cell RNA and in situ hybridization are limited by missing spatial context and low throughput, respectively. We present a...

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PMID: 38534368
DOI: 10.3390/cells13060522

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