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Spatial transcriptomic interrogation of the murine bone marrow signaling landscape

6 Nov 2023

Abstract excerpt

Self-renewal and differentiation of skeletal stem and progenitor cells (SSPCs) are tightly regulated processes, with SSPC dysregulation leading to progressive bone disease. While the application of single-cell RNA sequencing (scRNAseq) to the bone field has led to major advancements in our understanding of SSPC heterogeneity, stem cells are tightly regulated by their neighboring cells which comprise the bone...

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PMID: 37926705
DOI: 10.1038/s41413-023-00298-1

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