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Spatial Transcriptome Analysis Reveals Diverse Human Burn Wound Microenvironment

28 Jun 2025

Abstract excerpt

Histologic analyses of burn tissue are unable to discern reversible injury. Advanced molecular profiling, such as bulk RNA-sequencing, provides more detail; however, these methods lose spatial context. Spatial transcriptomics allows gene transcripts to be mapped to tissue locations, revealing the molecular pathways activated in the burn tissue microenvironment, where the depth of injury guides prognosis. This...

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PMID: 40579885
DOI: 10.1111/wrr.70061

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