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Article

Paternal aging impacts expression and epigenetic markers as early as the first embryonic tissue lineage differentiation

26 Mar 2024

Abstract excerpt

BACKGROUND: Advanced paternal age (APA) is associated with adverse outcomes to offspring health, including increased risk for neurodevelopmental disorders. The aim of this study was to investigate the methylome and transcriptome of the first two early embryonic tissue lineages, the inner cell mass (ICM) and the trophectoderm (TE), from human blastocysts in association with paternal age and disease risk. High...

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PMID: 38532526
DOI: 10.1186/s40246-024-00599-4

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