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Transcript profiling and gene regulation of the human pre-implantation embryo: parental effects and impact of ARTs

1 Aug 2025

Abstract excerpt

BACKGROUND: Infertility is a growing global challenge, with ARTs significantly improving birth rates for infertile couples. However, ART conceptions are associated with a higher risk of negative obstetrical and perinatal outcomes, with potential long-term effects on offspring health. Many pre-implantation embryos exhibit abnormal morphokinetics, implantation failure, or arrested development. ART procedures and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 40891422
DOI: 10.1093/humupd/dmaf022

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