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Digital counting of tissue cells for molecular analysis: the QuANTUM pipeline

26 Mar 2024

Abstract excerpt

The estimation of tumor cellular fraction (TCF) is a crucial step in predictive molecular pathology, representing an entry adequacy criterion also in the next-generation sequencing (NGS) era. However, heterogeneity of quantification practices and inter-pathologist variability hamper the robustness of its evaluation, stressing the need for more reliable results. Here, 121 routine histological samples from...

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PMID: 38532196
DOI: 10.1007/s00428-024-03794-9

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