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Evaluating Diff-Quik cytology smears for large-panel mutation testing in lung cancer-Predicting DNA content and success with low-malignant-cellularity samples.

Cancer cytopathology - 1 Jun 2023

Fielding David I, Dalley Andrew J, Singh Mahendra, Nandakumar Lakshmy, Lakis Vanessa, Chittoory Haarika, Fairbairn David, Patch Ann-Marie, Kazakoff Stephen H, Ferguson Kaltin, Bashirzadeh Farzad, Bint Michael, Pahoff Carl, Son Jung Hwa, Hodgson Alan, Sharma Sowmya, Waddell Nicola, Lakhani Sunil R, Hartel Gunter, Nones Katia, Simpson Peter T

Abstract excerpt

BACKGROUND: Cytology smears are commonly collected during endobronchial ultrasound-guided transbronchial needle aspiration (EBUS TBNA) procedures but are rarely used for molecular testing. Studies are needed to demonstrate their great potential, in particular for the prediction of malignant cell DNA content and for utility in molecular diagnostics using large gene panels. METHODS: A prospective study was...

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PMID: 36938641
DOI: 10.1002/cncy.22690

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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