Article
Adequately defining tumor cell proportion in tissue samples for molecular testing improves interobserver reproducibility of its assessment.
Virchows Archiv : an international journal of pathology - 1 Jan 2017
Lhermitte Benoît, Egele Caroline, Weingertner Noëlle, Ambrosetti Damien, Dadone Bérengère, Kubiniek Valérie, Burel-Vandenbos Fanny, Coyne John, Michiels Jean-François, Chenard Marie-Pierre, Rouleau Etienne, Sabourin Jean-Christophe, Bellocq Jean-Pierre
Abstract excerpt
Gene mutation status assessment of tumors has become standard practice in diagnostic pathology. This is done using samples comprising tumor cells but also non-tumor cells, which may dramatically dilute the proportion of tumor DNA and induce false negative results. Increasing sensitivity of molecular tests presently allows detection of a targeted mutation in a sample with a small percentage of tumor cells, but...
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