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Article

qpure: A tool to estimate tumor cellularity from genome-wide single-nucleotide polymorphism profiles.

PloS one - 1 Jan 2012

Song Sarah, Nones Katia, Miller David, Harliwong Ivon, Kassahn Karin S, Pinese Mark, Pajic Marina, Gill Anthony J, Johns Amber L, Anderson Matthew, Holmes Oliver, Leonard Conrad, Taylor Darrin, Wood Scott, Xu Qinying, Newell Felicity, Cowley Mark J, Wu Jianmin, Wilson Peter, Fink Lynn, Biankin Andrew V, Waddell Nic, Grimmond Sean M, Pearson John V

Abstract excerpt

Tumour cellularity, the relative proportion of tumour and normal cells in a sample, affects the sensitivity of mutation detection, copy number analysis, cancer gene expression and methylation profiling. Tumour cellularity is traditionally estimated by pathological review of sectioned specimens; however this method is both subjective and prone to error due to heterogeneity within lesions and cellularity...

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PMID: 23049875
DOI: 10.1371/journal.pone.0045835
PMCID: PMC3457972

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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