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Article

Pathologically Confirmed Alzheimer's Disease in APOE ɛ2 Homozygotes is Rare but Does Occur.

Journal of Alzheimer's disease : JAD - 1 Jan 2018

Stipho Faissal, Jackson Robert, Sabbagh Marwan N

Abstract excerpt

BACKGROUND: Homozygous APOEɛ4 status is a well-known risk factor in the development of Alzheimer's disease (AD). However, other genotypes of APOE have not yet been found to have equal clinical significance. There is a paucity of reports regarding clinically or pathologically described AD in APOEɛ2 homozygotes compared to the other alleles. OBJECTIVE: To notify clinicians that patients with homozygous APOEɛ2 are...

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Source

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Identifiers

PMID: 29562509
DOI: 10.3233/JAD-171060
PMCID: PMC6655477

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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