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Article

Cortical thickness is differently associated with ALDH2 rs671 polymorphism according to level of amyloid deposition.

Scientific reports - 30 Sept 2021

Cho Yong Hyuk, Lee Heirim, Kim Na-Rae, Choi Jin Wook, Roh Hyun Woong, Ha Jae Ho, Hong Chang Hyung, Seo Sang Won, Choi Seong Hye, Kim Eun-Joo, Kim Byeong C, Kim Seong Yoon, Cheong Jaeyoun, Park Bumhee, Son Sang Joon

Abstract excerpt

Accumulating evidence indicates that amyloid-beta (Aβ) deposition and biogenic aldehyde accumulation contribute to the pathogenesis of neurodegenerative diseases. Human aldehyde dehydrogenase 2 (ALDH2) metabolizes biogenic aldehydes produced in the brain to prevent damage. However, r671G>A, a single nucleotide polymorphism of ALDH2, causes aldehyde accumulation and decreased ALDH2 activity. We aimed to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34593890
DOI: 10.1038/s41598-021-98834-8
PMCID: PMC8484554

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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