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Article

Lhx6 and Lhx8 promote palate development through negative regulation of a cell cycle inhibitor gene, p57Kip2.

Human molecular genetics - 1 Sept 2015

Cesario Jeffry M, Landin Malt Andre, Deacon Lindsay J, Sandberg Magnus, Vogt Daniel, Tang Zuojian, Zhao Yangu, Brown Stuart, Rubenstein John L, Jeong Juhee

Abstract excerpt

Cleft palate is a common birth defect in humans. Therefore, understanding the molecular genetics of palate development is important from both scientific and medical perspectives. Lhx6 and Lhx8 encode LIM homeodomain transcription factors, and inactivation of both genes in mice resulted in profound craniofacial defects including cleft secondary palate. The initial outgrowth of the palate was severely impaired in...

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Share to Cyclin-Dependent Kinase Inhibitor p57
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 26071365
DOI: 10.1093/hmg/ddv223
PMCID: PMC4527495

Genes

LHX6
LHX8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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