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Article

The facial neural crest controls fore- and midbrain patterning by regulating Foxg1 expression through Smad1 activity.

Development (Cambridge, England) - 1 Jun 2014

Aguiar Diego P, Sghari Soufien, Creuzet Sophie

Abstract excerpt

The facial neural crest (FNC), a pluripotent embryonic structure forming craniofacial structures, controls the activity of brain organisers and stimulates cerebrum growth. To understand how the FNC conveys its trophic effect, we have studied the role of Smad1, which encodes an intracellular transducer, to which multiple signalling pathways converge, in the regulation of Foxg1. Foxg1 is a transcription factor...

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PMID: 24917504
DOI: 10.1242/dev.101790

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