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Article

APOE ε4 carriage associates with improved myocardial performance from adolescence to older age.

BMC cardiovascular disorders - 21 Mar 2024

Topriceanu Constantin-Cristian, Shah Mit, Webber Matthew, Chan Fiona, Shiwani Hunain, Richards Marcus, Schott Jonathan, Chaturvedi Nishi, Moon James C, Hughes Alun D, Hingorani Aroon D, O'Regan Declan P, Captur Gabriella

Abstract excerpt

BACKGROUND: Although APOE ε4 allele carriage confers a risk for coronary artery disease, its persistence in humans might be explained by certain survival advantages (antagonistic pleiotropy). METHODS: Combining data from ~ 37,000 persons from three older age British cohorts (1946 National Survey of Health and Development [NSHD], Southall and Brent Revised [SABRE], and UK Biobank) and one younger age cohort (Avon...

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Identifiers

PMID: 38509472
DOI: 10.1186/s12872-024-03808-z
PMCID: PMC10956279

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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