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Article

Apolipoprotein E Genotype Modifies the Association Between Cardiac Output and Cognition in Older Adults.

Journal of the American Heart Association - 6 Aug 2019

Bown Corey W, Liu Dandan, Osborn Katie E, Gupta Deepak K, Mendes Lisa A, Pechman Kimberly R, Hohman Timothy J, Wang Thomas J, Gifford Katherine A, Jefferson Angela L

Abstract excerpt

Background Subtle reductions in cardiac output relate to lower cerebral blood flow, especially in regions where Alzheimer's disease pathology first develops. Apolipoprotein E (APOE)-ε4 is a genetic susceptibility risk factor for Alzheimer's disease that also moderates vascular damage. This study investigated whether APOE-ε4 carrier status modifies the cross-sectional association between cardiac output and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 31364446
DOI: 10.1161/JAHA.118.011146
PMCID: PMC6761646

Genes

APOE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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