Article
Apolipoprotein E4 Is Associated with Right Ventricular Dysfunction in Dilated Cardiomyopathy-An Animal and In-Human Comparative Study.
International journal of molecular sciences - 7 Sept 2021
Diaconu Rodica, Schaaps Nicole, Afify Mamdouh, Boor Peter, Cornelissen Anne, Florescu Roberta A, Simsekyilmaz Sakine, El-Khoury Teddy, Schumacher David, Ioana Mihai, Streata Ioana, Militaru Constantin, Donoiu Ionut, Vogt Felix, Liehn Elisa A
Abstract excerpt
ApoE abnormality represents a well-known risk factor for cardiovascular diseases. Beyond its role in lipid metabolism, novel studies demonstrate a complex involvement of apoE in membrane homeostasis and signaling as well as in nuclear transcription. Due to the large spread of apoE isoforms in the human population, there is a need to understand the apoE's role in pathological processes. Our study aims to dissect...
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