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Article

Apolipoprotein E4 and coronary heart disease in middle-aged men who smoke: a prospective study.

Lancet (London, England) - 14 Jul 2001

Humphries S E, Talmud P J, Hawe E, Bolla M, Day I N, Miller G J

Abstract excerpt

BACKGROUND: The common isoforms of apolipoprotein E (apoE), E2, E3, and E4, are important determinants of plasma lipid concentrations, and the epsilon4 allele is associated with raised risk of coronary heart disease. We investigated whether the effect of smoking on coronary heart disease risk is affected by APOE genotype. METHODS: We enrolled 3052 middle-aged men who were free of coronary heart disease for...

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Source

Identifiers

PMID: 11463413
DOI: 10.1016/S0140-6736(01)05330-2

Genes

APOE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Apolipoprotein E4 and coronary heart disease in middle-aged men who smoke: a prospective study.PMID 11463413Read ↗

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