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Engineering Large-Scale and Innervated Functional Human Gut for Transplantation

2025-05-27

Abstract excerpt

A confined culture system (CCS) establishes methods to generate complex functional human gastrointestinal tissues. This approach yields large-scale innervated small intestinal, colonic and gastric organoids with an elongated tubular shape for both in vitro and in vivo studies. Transcriptomic and electrophysiological data demonstrate the co-development of a functional de novo enteric nervous system, which is absent...

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Identifiers and source

Literature Corpus work
6d417431-b4a6-5bcf-9ef9-9b7655a833ae
DOI
10.1101/2025.05.22.655510
Open publication

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Engineering Large-Scale and Innervated Functional Human Gut for TransplantationDOI 10.1101/2025.05.22.655510
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