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Article

Transplanted progenitors generate functional enteric neurons in the postnatal colon.

The Journal of clinical investigation - 1 Mar 2013

Hotta Ryo, Stamp Lincon A, Foong Jaime P P, McConnell Sophie N, Bergner Annette J, Anderson Richard B, Enomoto Hideki, Newgreen Donald F, Obermayr Florian, Furness John B, Young Heather M

Abstract excerpt

Cell therapy has the potential to treat gastrointestinal motility disorders caused by diseases of the enteric nervous system. Many studies have demonstrated that various stem/progenitor cells can give rise to functional neurons in the embryonic gut; however, it is not yet known whether transplanted neural progenitor cells can migrate, proliferate, and generate functional neurons in the postnatal bowel in vivo. We...

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Identifiers

PMID: 23454768
DOI: 10.1172/JCI65963
PMCID: PMC3582137

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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