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Interferon regulatory factor 7 mediates obesity-associated MCP-1 transcription

21 May 2020

Abstract excerpt

Hypertrophy, associated with adipocyte dysfunction, causes increased pro-inflammatory adipokine, and abnormal glucose and lipid metabolism, leading to insulin resistance and obesity-related-health problems. By combining DNA microarray and genomic data analyses to predict DNA binding motifs, we identified the transcription factor Interferon Regulatory Factor 7 (IRF7) as a possible regulator of genes related to...

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PMID: 32437400
DOI: 10.1371/journal.pone.0233390

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