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Inhibition of Interferon Regulatory Factor 7 (IRF7)-Mediated Interferon Signal Transduction by the Kaposi's Sarcoma-Associated Herpesvirus Viral IRF Homolog vIRF3

24 May 2007

Abstract excerpt

Upon viral infection, the major defense mounted by the host immune system is activation of the interferon (IFN)-mediated antiviral pathway that is mediated by IFN regulatory factors (IRFs). In order to complete their life cycle, viruses must modulate the host IFN-mediated immune response. Kaposi's sarcoma-associated herpesvirus (KSHV), a human tumor-inducing herpesvirus, has developed a unique mechanism for...

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Cancer-related molecular mechanisms research
interferon and immune responses
Viral-associated cancers and disorders

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 17522209
DOI: 10.1128/jvi.00235-07

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