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Harnessing conserved signaling and metabolic pathways to enhance the maturation of functional engineered tissues

3 Sept 2022

Abstract excerpt

The development of induced-pluripotent stem cell (iPSC)-derived cell types offers promise for basic science, drug testing, disease modeling, personalized medicine, and translatable cell therapies across many tissue types. However, in practice many iPSC-derived cells have presented as immature in physiological function, and despite efforts to recapitulate adult maturity, most have yet to meet the necessary...

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PMID: 36057642
DOI: 10.1038/s41536-022-00246-3

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