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Article

Metabolic oxidation regulates embryonic stem cell differentiation.

Nature chemical biology - 1 Jun 2010

Yanes Oscar, Clark Julie, Wong Diana M, Patti Gary J, Sánchez-Ruiz Antonio, Benton H Paul, Trauger Sunia A, Desponts Caroline, Ding Sheng, Siuzdak Gary

Abstract excerpt

Metabolites offer an important unexplored complementary approach to understanding the pluripotency of stem cells. Using MS-based metabolomics, we show that embryonic stem cells are characterized by abundant metabolites with highly unsaturated structures whose levels decrease upon differentiation. By monitoring the reduced and oxidized glutathione ratio as well as ascorbic acid levels, we demonstrate that the stem...

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Identifiers

PMID: 20436487
DOI: 10.1038/nchembio.364
PMCID: PMC2873061

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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