Article

Stage-resolved iPSC-to-motoneuron differentiation: Metabolic switch & mitochondrial remodeling

2026-03-30

Abstract excerpt

Development of motoneurons from stem cells is characterized by a change from glycolytic to oxidative metabolism. Since this transition remains poorly understood, we examined it at five distinct differentiation stages from hiPSC to motoneuron. While a direct comparison of hiPSCs and mature motoneurons confirmed the expected glycolytic-to-oxidative shift, the intermediate stages showed that the conversion was not mo...

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Literature Corpus work: 7fefb879-a9bc-5cb5-9422-856ca1785dd6
DOI: 10.64898/2026.03.25.714145

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