Active mitochondria in healthy spiny mouse fibroblasts resemble megamitochondria and remain resilient across lifespan

Abstract excerpt

<h4>ABSTRACT</h4> Although they exhibit limited regenerative ability of some tissues and organs shortly after birth or towards the end of fetal development, humans and laboratory mammals quickly transition to producing scar tissue for tissue repair. In contrast, spiny mice exhibit complex tissue regeneration as adults and provide a blueprint for how regeneration can occur throughout adulthood in mammals. Fibrobla...

Topics

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• Autophagy in Disease and Therapy
• Cells, Cultured
• Energy Metabolism
• Fatty Acids
• Induced Pluripotent Stem Cells
• Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
• Mesenchymal stem cell research
• MicroRNA in disease regulation

Identifiers and source

Literature Corpus work

e84fba6e-0290-5c78-822d-abeb82f8dadc

DOI

10.1101/2025.10.02.680123